NKIRAS1 Antibody, FITC conjugated

Code CSB-PA885767LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NKIRAS1 Polyclonal antibody
Uniprot No.
Target Names
NKIRAS1
Alternative Names
2400004O09Rik antibody; I kappa B interacting Ras like protein 1 antibody; I-kappa-B-interacting Ras-like protein 1 antibody; Kappa B Ras 1 antibody; Kappa B Ras protein 1 antibody; Kappa B-Ras protein 1 antibody; KappaB Ras1 antibody; KappaB-Ras1 antibody; KBRAS 1 antibody; KBRAS1 antibody; KBRS1_HUMAN antibody; NF kappa B inhibitor interacting Ras like protein 1 antibody; NF-kappa-B inhibitor-interacting Ras-like protein 1 antibody; NFKB inhibitor interacting Ras like 1 antibody; NFKB inhibitor interacting Ras like protein 1 antibody; NKIRAS 1 antibody; nkiras1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 1 protein (1-192AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Gene References into Functions
  1. It was demonstrated that elevated levels of mRNA for NKIRAS1 was significantly associated both with loss of methylation in NKIRAS1 CpG-islands and methylation in a number of miRNA genes. PMID: 25869366
  2. Significant correlation was found between alterations of methylation status of miR-34b/c, miR-193a and the expression level of NKIRAS1 target gene in the primary lung tumors. PMID: 23156677
  3. Low kappaB-Ras1 expression is associated with gliomas. PMID: 21302000
  4. It was shown the decreased expression level of NKIRAS1 in Renal cell carcinoma PMID: 20693965
Subcellular Location
Cytoplasm.
Protein Families
Small GTPase superfamily, Ras family, KappaB-Ras subfamily
Tissue Specificity
Widely expressed.
Database Links

HGNC: 17899

OMIM: 604496

KEGG: hsa:28512

STRING: 9606.ENSP00000373411

UniGene: Hs.173202

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